In 1967, a pregnant woman is attacked by a vampire, causing her to go into premature labor. Doctors are able to save her baby, but the woman dies.

Thirty years later, the child has become the vampire hunter, Blade, who is a human-vampire hybrid that possesses the supernatural abilities of the vampires without any of their weaknesses, except for the requirement to consume human blood. Blade raids a rave club in Los Angeles owned by the vampire Deacon Frost. Police take one of the vampires to the hospital, where he kills Dr. Curtis Webb and feeds on hematologist

 Karen Jenson, and escapes. Blade takes Karen to a safe house where she is treated by his old friend Abraham Whistler. Whistler explains that he and Blade have been waging a secret war against vampires using weapons based on their elemental weaknesses, such as sunlight, silver, and garlic. As Karen is now “marked” by the bite of a vampire, both he and Blade tell her to leave the city.

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