Former United Nations investigator Gerald “Gerry” Lane, his wife, Karin, and their two daughters, Rachel and Connie are caught in traffic at downtown Philadelphia when zombies invade. During the ensuing chaos, they escape to Newark where they seek shelter with a couple and their young son, Tommy. The next day, Gerald tries to convince Tommy’s family to join his, as staying is not safe. However, Tommy’s father refuses. The Lanes head to the roof of the apartment block. Not long after, zombies break into the apartment and turn everyone there but Tommy, who escapes. The Lanes are ambushed on the stairwell.

Gerald holds them off so Karin and the girls can get to the roof. He is saved by Tommy, who Gerald grabs and takes with him. On the roof, they are rescued by a helicopter sent by Thierry Umutoni, the UN Deputy Secretary-General. The group is then taken to a US Navy vessel stationed in the Atlantic Ocean, where a team of scientists are studying the outbreak. Among them is virologist Andrew Fassbach, who believes that the plague is caused by a virus and finding its origin is crucial for developing a vaccine. Faced with the threat of eviction from the vessel, Gerry reluctantly agrees to assist Fassbach.

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