Two days before his wedding, bachelor Doug Billings travels to Las Vegas with his best friends Phil Wenneck, a sarcastic elementary school teacher, Stu Price, an apprehensive dentist, and Alan Garner, his odd future brother-in-law. Sid, the father of Doug’s fiancée Tracy, loans Doug his vintage Mercedes-Benz W111 to drive to Vegas. They book a suite at Caesars Palace and celebrate by sneaking onto the hotel rooftop and taking shots of Jägermeister. The next day, Phil, Stu and Alan awaken, unable to remember the previous night. Doug is nowhere to be found, Stu’s tooth is missing, the suite is a mess, a Bengal tiger is in the bathroom, and a baby is in the closet. They see Doug’s mattress impaled on a statue outside, and when they ask for their Mercedes, the valet delivers a Las Vegas police cruiser.

Retracing their steps, the trio travel to a hospital, discovering they were drugged with Rohypnol, causing their memory loss, and that they went to the hospital from a chapel the previous night. At the chapel, they learn that Stu married a call girl named Jade, despite being in a relationship with his domineering and philandering girlfriend Melissa. Outside the chapel, the trio is attacked by gangsters demanding to know where “he” is. Bewildered, they flee and track down Jade, who is revealed to be the baby’s mother.

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