In 1947 Los Angeles, animated cartoon characters, or “toons“, co-exist with humans, often employing their skills to entertain as film stars. Private detective Eddie Valiant, once a staunch ally of the toons alongside his twin brother Teddy, has become a depressed alcoholic following Teddy’s murder by an unknown toon five years earlier. Maroon Cartoon Studios head, R.K. Maroon, upset about the recent poor performance of his toon star Roger Rabbit, hires Eddie to investigate rumors that Roger’s glamorous toon wife Jessica is having an affair with Marvin Acme, owner of both the Acme Corporation and Toontown, the animated metropolis in which toons reside.

After watching Jessica perform at The Ink and Paint Club, Eddie secretly photographs her and Acme playing patty-cake. He shows the pictures to Roger, who becomes distraught and flees, refusing to believe Jessica was unfaithful. The next morning, Acme is found dead and evidence at the scene implicates Roger as a suspect. Eddie meets Judge Doom, the sinister human judge of Toontown—having bribed the electorate to gain their votes—and his five weasel minions, the Toon Patrol. Doom confirms he plans to execute Roger using the “Dip”, a chemical concoction of acetonebenzene, and turpentine which is capable of destroying the otherwise invulnerable toons.

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