A highly contagious, aggression-inducing virus called the “rage virus” is unleashed in Great Britain after an infected chimpanzee is freed from its cage in a laboratory in Cambridge by a group of animal rights activists. Within seconds of exposure after freeing the enraged chimp, one of the activists succumbs to the virus and immediately infects another. Over the following hours and days, it spreads rapidly and becomes an epidemic, resulting in total societal collapse.

Twenty-eight days after the initial outbreak, bicycle courier Jim, who had an accident and fell into a coma prior to the outbreak, awakens in St Thomas’ Hospital in London, which has been completely deserted with visible signs of catastrophe. After wandering the streets of London and entering a church, Jim is chased by infected humans before being rescued by survivors Selena and Mark, who take Jim to their place of refuge in a streetside store. At Jim’s request, the group travels by foot to his parents’ house in Deptford, where he learns that they died by suicide, leaving him a note. Shortly thereafter, Mark gets a cut on his arm which is exposed to infected blood during an attack, prompting Selena to immediately kill him before he can turn.

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